More work still needed for a vaccine, say experts, Latest Singapore News - The New Paper

More work still needed for a vaccine, say experts

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Human trials of three vaccines did not cause dangerous side effects, led to protective response from body

The global fight against Covid-19 received a boost on Monday with the release of encouraging findings from human trials of three coronavirus vaccines, including a closely watched one being developed by Oxford University.

The results showed that the vaccines being tested did not cause any dangerous side effects, and that they could coax a protective response from the human body.

But experts said that while the results were encouraging, much more work is still needed to plug remaining gaps in knowledge before a vaccine can be made commercially available.

Speaking at a media conference on Monday, Dr Michael Ryan, executive director of the World Health Organisation's health emergencies programme, noted that the findings were from trials in their early stages and the data is very new.

"We now need to move into larger-scale, real-world trials," he said.

"But it is good to see more data, and more products moving into this very important phase of vaccine discovery, and we congratulate our colleagues for the progress they have made."

The latest findings were from early phases of clinical trials for vaccines being developed by Oxford University and multinational drugmaker AstraZeneca; CanSino Biologics and China's military research unit; and German biotech company BioNTech and US drugmaker Pfizer.

All three studies - two were published in medical journal The Lancet, while the Pfizer study was published as a pre-print pending peer review - found that the vaccine candidates could stimulate the body to produce immune system "soldiers", such as antibodies or T-cells, which help the body fight off invading pathogens.

Professor Stephen Evans from the London School of Hygiene and Tropical Medicine, noted that for the Oxford trial, the immune responses measured in the blood, and the absence of serious harms indicate there is a possibility of an effective vaccine.


The Oxford vaccine had prompted an antibody and a T-cell response - both of which may be important in the protection against Covid-19.

However, he also noted that there were some gaps.

"It does not yet show that the disease is reduced or prevented, and this will not be easy to show until Phase III trials have been completed in settings where the (virus) is circulating at a high rate and people are getting clinical and severe disease," Prof Evans was quoted as saying in a CNN report.

Clinical development is a three-phase process, the US Centres for Disease Control and Prevention says on its website.

In Phase I, small groups of people receive the trial vaccine, and this is expanded in Phase II to include people who have characteristics, such as age and physical health, similar to those for whom the new vaccine is intended. In Phase III, the vaccine is given to thousands and tested for efficacy and safety.

In an update on Monday, AstraZeneca said late-stage Phase II/III trials are currently under way in Britain, Brazil and South Africa and are due to start in the US.